Cobalt oxide nanoparticles mediate tau denaturation and cytotoxicity against PC-12 cell line
M Nouri, N Esfahanizadeh, MG Shahpar, F Attar… - International journal of …, 2018 - Elsevier
It has not been well explored how NPs may induce some adverse effects on the biological
systems. In this research, the interaction of cobalt oxide NPs (Co 3 O 4 NPs) with tau protein
and PC-12 cell line, as nervous system models, was investigated with several approaches
including fluorescence spectroscopy, CD spectroscopy, docking study, MTT, LDH, AO/EB
dual staining, and flow cytometry assays. Fluorescence investigation displayed that Co 3 O 4
NPs spontaneously mediate the formation of a static complex with tau protein through …
systems. In this research, the interaction of cobalt oxide NPs (Co 3 O 4 NPs) with tau protein
and PC-12 cell line, as nervous system models, was investigated with several approaches
including fluorescence spectroscopy, CD spectroscopy, docking study, MTT, LDH, AO/EB
dual staining, and flow cytometry assays. Fluorescence investigation displayed that Co 3 O 4
NPs spontaneously mediate the formation of a static complex with tau protein through …
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